TNF and Hypertension: Nevertheless, a meta-analysis by Takagi et al. revealed that treatment of hypertensive adults with telmisartan significantly reduced IL-6 and TNFα concentrations [58], and a meta-analysis by Soltani et al. showed that adherence to the DASH (Dietary Approaches to Stop Hypertension) diet statistically significantly reduced hs-CRP concentrations in adults [59].