The incidence of a significant pericardial effusion requiring intervention after LAAO is reported to be approximately 1.3%, with risk factors including advanced age, higher CHA2DS2-VASC score, obesity, female sex, left ventricular dysfunction, paroxysmal atrial fibrillation, prior bleeding, lower serum albumin, pre-procedural dual antiplatelet therapy, sinus rhythm during the procedure, and moderate sedation rather than general anesthesia [22,23]. The gene discussed is ALB; the disease is Obesity.