Of note, the distinction between tissue ACE2 (cACE2) and plasma ACE2 (=soluble ACE2, sACE2) is crucial, as sACE2 retains an intact SARS-CoV-2 binding site after being shed from cACE2, leading to various theories about its role in the virus’s mechanism of infection and potential treatment strategies [27,31,32,36,37,38]. Here, ACE2 is linked to infection.