Importantly, the International Severe Asthma Registry (ISAR), the global registry for adults with severe asthma—the largest repository of real-world data on severe asthma, curating data on nearly 35,000 patients from 28 countries worldwide—clearly revealed that there are overlapping pathogenic pathways based on used biomarkers (IgE, FeNO, blood eosinophils) in 65% of enrolled patients [30,31]. The gene discussed is IGHE; the disease is asthma.