On this basis, the present work pursues two goals: (1) to characterise the diabetes subgroups in HS based on the foundations of the ANDIS clustering [28] approach and (2) to investigate the interaction between insulin–glucose homeostasis, diabetes mellitus and the haptoglobin concentrations in patients with inflammatory processes that interact and determine to what extent they affect the clinical pattern of HS. The gene discussed is HP; the disease is diabetes mellitus.