Furthermore, the median levels of ESR (18 mm/h vs. 11 mm/h, p = 0.041) were significantly higher among those women with WHO Class II/III obesity, along with a tendency towards higher HOMA-IR values (3.28 vs. 2.73, p = 0.097) and lower TSP1 and ET1 levels, suggesting the potential effect of obesity severity on these parameters, even before significant alterations in glucose levels, lipid profiles, liver enzymes, or coagulation parameters were observed during disease progression (Table 2). The gene discussed is EDN1; the disease is obesity due to melanocortin 4 receptor deficiency.