The Spearman correlation revealed that ET1 was positively correlated with AST (r = 0.425, p < 0.01), ALT (r = 0.340, p < 0.05), Gamma-GT (r = 0.299, p < 0.05), and triglycerides (r = 0.282, p < 0.05) in premenopausal women with obesity. The gene discussed is GPT; the disease is obesity due to melanocortin 4 receptor deficiency.