In the final models, SHBG explained 2.4% of the variance in LVEF values (Supplemental Table S4), 6.9% of the variance in LVDD values (Supplemental Table S5), 1.4% of the variance in NYHA Class values (Supplemental Table S6), and 1.1% of the variance in the duration of HF (Supplemental Table S7). This evidence concerns the gene SHBG and hydrops fetalis.