PDX1 and familial pancreatic carcinoma: To test the regulatory role of these mutant p53 forms on the pancreatic cancer lipid profile, we carried out a global untargeted lipidomic profiling in KPC cells derived from mouse PDAC, generated by the pancreas-specific expression of the constitutively active KRASG12D (pdx1-CRE LSL-KRASG12D) and mutant-p53 R172H or R270H expression.