NLRP3 and glioma: In addition, in an in vitro model of glioma cells, BHB was shown to reduce the levels of activated cysteine aspartate-specific protease 1 and mature IL-1β, which in turn inhibited the migration of C6 glioma cells in vitro and the activation of NLRP3 inflammasomes, thereby reducing the inflammatory microenvironment and the inflammatory response [14].