Variants in SCN1A give rise to a wide range of epilepsy syndromes, ranging from mild familial febrile seizures (FEB) [4], and genetic epilepsy with febrile seizures plus (GEFS +) [5], to severe developmental and epileptic encephalopathy (DEE) or Dravet syndrome (DS) [6–8]. Here, SCN1A is linked to developmental and epileptic encephalopathy.