Similarly, a former study reported the neuroprotective action of MH on the 3-NP-induced HD model via modulation of glutamate/calpain axis, Kidins220, and brain-derived neurotrophic factor, tropomyosin-related kinase receptor B, protein kinase B, and cAMP response element-binding protein trajectory (Mohamed et al. 2023). This evidence concerns the gene BDNF and Huntington disease.