SCN2A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: Other forms of epileptic syndromes caused by mutations in VGSCs are generalized (genetic) epilepsy with febrile seizure plus + (GEFS), a milder form of epilepsy compared to Dravet syndrome, resulted from the mutations of SCN1A and SCN1B (which encodes the β1 subunit of nACHR); and BFNIS, which is caused by mutations in SCN2A, a gene encoding one of the α-subunits of VGSCs.