Among the genetic-idiopathic epilepsies in which VGSCs are implicated, Dravet syndrome (also known as SMEI) is a type of highly debilitating, recalcitrant and pharmacoresistant epilepsy resulted from missense mutations in the VGSC protein NaV1.1 encoded by the SCN1A gene [43]. Here, SCN1A is linked to encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.