SLC19A3 and biotin-responsive basal ganglia disease: In 2017, China Xuanwu Hospital proposed the following diagnostic criteria for BTBGD [69]: (i) subacute onset in early childhood; (ii) presence of seizures; (iii) manifestation of dystonia; (iv) display of ataxia; (v) presence of similar symptoms in other family members or children’s parents are consanguineous; (vi) identification of abnormal signals in the head and shell nuclei of the bilateral caudate nuclei visible on head MRI; (vii) absence of a better explaination by other diseases; (viii) genetic examination confirming the homozygous or heterozygous mutation of the SLC19A3 gene.