By broadening our perspective to incorporate the KEGG pathways, we also observed that ERBB2 (Hypo), NCK1 (Hypo), and JUN (Hyper) are members of the ErbB signaling pathway, while BDNF (Hyper) and JUN (Hyper) are constituents of the Cocaine addiction pathway. The gene discussed is ERBB2; the disease is cocaine dependence.