GJD2 and epilepsy: Activating metabotropic glutamate receptors can increase Cx36 expression in neurons in a mouse model with 4-aminopyridine-induced epilepsy, while the expression of Cx36 can be effectively reduced by inactivating metabotropic glutamate receptors, which suggests a correlation between Cx36 and the glial transmitter glutamate during epileptic seizures [64].