In addition, some studies have established zebrafish models that mimic human ADSL deficiency (National Natural Science Foundation of China, Project Number: 81371264), the developmental defects of monoamine neurons and gabaergic neurons in ADSL deficient embryos were found by transgenic marker fish lines, which were associated with the lack of AMP development at early embryonic stage, leading to neurological symptoms such as epilepsy. This evidence concerns the gene ADSL and epilepsy.