CLOCK and epilepsy: Two mechanisms have been proposed to elucidate the impact of the circadian clock on seizures: one suggests that canonical clock genes, such as Bmal1 (basic helix-loop-helix Arnt like 1) and Clock (clock circadian regulator), directly contribute to epilepsy, while the other posits that the circadian clock operates through specific signaling pathways to influence epilepsy [42].