NSMCE2 and Insulin resistance: In addition, we found that of the six genes with high-frequency mutations, NSMCE2 [20], MYO10 [21], ADGRL3 [22], and PCDH7 [23] were all associated with abnormal glucose metabolism or insulin resistance, which is consistent with the unique PCOS phenotype of the Group B. Among them, NSMCE2 and PCDH7 also showed high-frequency mutations in Group A. These two genes may not be associated with patients' susceptibility to adverse effects of ASMs.