In summary, previous studies have indicated that the NR2F1-related epilepsy is primarily attributed to haploinsufficiency of the Nr2f1 protein caused by NR2F1 variants, as Nr2f1 plays a role in maintaining the normal number and migration of interneurons, as well as the normal excitability of excitatory neurons in brain development. This evidence concerns the gene NR2F1 and epilepsy.