MAPT and Alzheimer disease: Regarding the hippocampus, in our AD sample, which consisted entirely of amyloid-β positive individuals, women showed atrophy earlier in the disease than men, this faster rate of hippocampal volume loss is consistent with Koran et al. [22], who described women to exhibit a faster rate of hippocampal volume loss in the presence of high CSF total tau and low CSF Amyloid-β 42.