INS and obesity due to melanocortin 4 receptor deficiency: The inclusion criterias were: (1) study design was RCT; (2) population was obesity, overweight, or aiming to lose weight; (3) intervetnion of experimental group should be PBM; (4) the control group should be exercise or diet or sham PBM; (5) the outcomes are weight, BMI (Body mass index), waistline, fat mass percentage, WHR (Waist-to-hip ratio), TC (Total cholesterol), HOMA-IR (Homeostasis model of assessment for insulin resistence index), Insulin, and CRP (C-reactive protein).