Scholars have used PBM for treating rheumatoid arthritis.The results demonstrate a significant reduction in plasma malondialdehyde (MDA), serum nitrate and nitrite levels, serum C-reactive protein (CRP) levels, plasma interleukin- 6 (IL- 6) levels, and glutathione peroxidase (GPx) activity, as well as erythrocyte sedimentation rate (ESR) in patients exposed to laser treatment compared to their pre-treatment levels (p < 0.0005) [39]. The gene discussed is CRP; the disease is rheumatoid arthritis.