LIPA and thrombocytosis disease: In addition, LAL activity in plasma was 2.5-fold increased (Fig. 4d), which fully corrected blood cell composition (Fig. 4e; Supplementary Fig. 4a), WBC counts (Fig. 4f), thrombocytosis (Fig. 4g; Supplementary Fig. 4b), and microcytic anemia (Supplementary Fig. 4c, e).