CD34– myCAFs express high levels of Lrrc15+, a marker of immunosuppressive fibroblasts that mediates resistance to immune checkpoint blockade in pancreatic cancer, and Col12a1, identified as a potential driver of invasion in breast cancer (Krishnamurty et al, 2022; Dominguez et al, 2020; Papanicolaou et al, 2022; Buechler et al, 2021). Here, COL12A1 is linked to familial pancreatic carcinoma.