TIMP2 and myopia: As shown in Fig. 8, the results indicated that the gene expression of PIK3R3, AKT2, BCL-2, E-cadherin, and MMP2 in the sclera of experimental myopic guinea pigs was significantly higher than the levels of the control animals after 2 weeks of myopia induction, whereas the mRNA expression of BAD, TGF-β1, COLI, and TIMP2 was decreased; in contrast, after 4-week myopia induction, PIK3R3, AKT2, and BCL-2 were decreased, whereas BAD was up-regulated.