As shown in Fig. 9, we noted that after 2 weeks of myopia induction, the levels of PIK3R3, and p-AKT2 in the sclera in the LIM group were significantly higher than the level of the NC group; however, after 4 weeks of myopia induction, the levels of PIK3R3 and p-AKT2 in the sclera in the LIM group decreased significantly compared with the level of the NC group (Fig. 9A, *P < 0.05, **P < 0.01, and ****P < 0.0001). Here, PIK3R3 is linked to myopia.