Further, we investigated the changes of PIK3R3, AKT2 and TGF-β1, E-cadherin, COLI, BCL-2, BAD, MMP2, and TIMP2 in the sclera of myopic guinea pigs to explore their effects on the development of myopia after 2- and 4-week myopic induction. The gene discussed is PIK3R3; the disease is myopia.