The role of different cell death pathways in T2D has also been intensively investigated in knock-out mouse models, mice lacking Caspase-8 in β-cells were protected from in vivo models of type 1 and type 2 diabetes, but with aging, these mice gradually developed hyperglycemia and a concomitant decline in β-cells mass, confirming that several different cell death pathways may play a role in T2D [161]. Here, CASP8 is linked to type 2 diabetes mellitus.