Knockdown of NLRP3 or caspase-1 reduced neuronal death and reversed cognitive impairments [147], whereas PARP-1 -/- mice were observed to prevent synaptic damage, cognitive dysfunction, and microglial activation in an AD mouse model referring to the significant role of pyroptosis and parthanathos in the pathogenesis of AD [148, 149]. Here, PARP1 is linked to Alzheimer disease.