NLRP3 and Alzheimer disease: Furthermore, the levels of key components of pyroptosis, NLRP3, caspase-1, GSDMD, IL-1β and IL-18 were also increased in PBMCs of AD patients [144], and GSDME is found to be highly expressed in the brain tissue and neurons of patients with neurodegenerative diseases executing its role in the pyroptotic pathway [145].