For instance, CDC25A expression was downregulated in kidney renal clear cell carcinoma (KIRC), CDC25B was downregulated in kidney chromophobe (KICH), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), ovarian serous cystadenocarcinoma (OV), prostate adenocarcinoma (PRAD), thyroid carcinoma (THCA), and uterine corpus endometrial carcinoma (UCEC), and CDC25C was downregulated in testicular germ cell tumors (TGCT) (Fig. 1B). This evidence concerns the gene CDC25B and squamous cell lung carcinoma.