SHROOM3 and chronic kidney disease: GWAS uncovered specific genetic variants linked to chronic kidney disease (CKD), such as those in the shroom family member 3 (SHROOM3) gene, which have been shown to contribute to kidney fibrosis.9,10 A study by Li et al. combined GWAS with epigenomic and transcriptomic resources and identified 41 genome-wide significant loci related to estimated glomerular filtration rate in individuals of African ancestry and those with ancestry in the Americas.