NEGR1 plays a role in axon extension, synaptic plasticity, synapse formation, and processes key neuronal functioning.52, 53, 54 Consistent with our finding, one study previously reported lower expression of UNC5C and UNC5D in endometriotic lesions compared to eutopic tissue of those without endometriosis.55 The gene discussed is UNC5C; the disease is endometriosis.