INS and type 1 diabetes mellitus: In a pilot open-label study with 20 adults with stage 3 T1D ofrecent-onset (<100 days), Marwaha e cols demonstrated that the intervention reducedthe percentage of circulating T helper 17, T helper 1, and T helper 17.1 cells as wellas proinsulin-specific T cells that secreted Interferon-γ and interleukin-17A(39).