•Abatacept (stage 1): No impact in progression to stage 2 or 3. •Hydroxychloroquine (stage 1): No impact on progression to stage 2 or 3.• GAD-Alum: No impact on progression to stage 3. • Insulin(oral/subcutaneous): No impact on progression to stage 3. •Teplizumab: Delays the progression of stage 3 in individuals with stage 2 T1D. This evidence concerns the gene INS and type 1 diabetes mellitus.