The main causes of this transient dysfunction seemto be AVP resistance due to downregulation of V2 receptors in the kidney associated with theuse of supraphysiologic intravenous vasopressin applied for several indications in ICUpatients, but also AVP-D due to COVID-19-associated posterior pituitary direct or indirect(delayed immune response) injury, endotoxin-mediated depletion of vasopressin stores inseptic shock, and impaired baroreceptor-mediated vasopressin secretion (19). This evidence concerns the gene AVP and COVID-19.