Genetic screening of hemochromatosis by next-generation sequencing ofall hemochromatosis-associated genes (HFE, HJV, HAMP, TFR2, andSLC40A1) revealed a heterozygotic variant (rs1799945) c.187C>Gp.(His63Asp) in HFE, a genotype not associated with iron overload. The gene discussed is TFR2; the disease is Tangier disease.