(28) included RCTs, observational studies,exploratory studies, mix of qualitative and quantitative studies to evaluate the effect of aGFD on growth, metabolic control and QoL in children and adolescents with T1DM and CD, andindicated that adherence to a GFD resulted in normal growth, steady BMI, and improved QoLwithout any adverse impact on HbA1c and insulin needs. The gene discussed is INS; the disease is type 1 diabetes mellitus.