Causal effect estimates (OR per 1 SD increase for all risk factors but per 1 year increase for age at menarche and age at menopause or per unit increase in the log odds for T2D and smoking) for each of the nine breast cancer risk factors across the five hormone receptor breast cancer subtypes are presented in Fig. 1 and Table 2. The gene discussed is NR4A1; the disease is type 2 diabetes mellitus.