A recent meta-analysis identified a significant association between CHIP and stroke risk, reporting a 16% increased risk of all strokes (HR: 1.16; 95% CI: 1.05–1.28) [186] and an 18% increased risk of ischemic stroke (HR: 1.18; 95% CI: 1.06–1.33). This evidence concerns the gene STUB1 and stroke disorder.