STUB1 and stroke disorder: Epidemiological studies consistently demonstrate that individuals with CHIP mutations, particularly in genes like DNMT3 A, TET2, ASXL1, and JAK2, have an increased risk of developing atherosclerotic diseases, including coronary artery disease, peripheral artery disease, myocardial infarction, and stroke [26, 27, 31, 35, 56, 59, 171, 183].