Antioxidant, anti-inflammatory, anti-apoptotic, and neuroprotective effects of ghrelin were reported in CNS disorders including epilepsy, traumatic brain injury, Parkinson and Alzheimer’s disease (Moon et al. 2009; Lopez et al. 2012; Sarlaki et al. 2022; Ergul Erkec et al. 2024a, b). The gene discussed is GHRL; the disease is early-onset autosomal dominant Alzheimer disease.