However, ghrelin has antioxidant (an increasing in SOD, GSH-Px and CAT levels), anti-inflammatory (a decreasing TNF-ɑ and IL- 6 levels according to the DM group), and neuroprotective (myelin loss-reducing and myelin content protective) effects in CPZ-induced MS model in rats which were reflected by increased antioxidant levels, decreased proinflammatory cytokine levels and remyelination. The gene discussed is TNF; the disease is myeloid sarcoma.