Recently, the role of SIRT3 in insulin resistance and redox signaling was reviewed; they describe that the activation of SIRT3 maintains a proper NADH/NAD+ and GSH/GSSG ratio and improves CI function and ß-Ox (Cortés-Rojo et al. 2020), emphasizing the importance of NAD+ and glutathione redox status in ß-Ox activation and a possible application in kidney diseases. Here, SIRT3 is linked to kidney disorder.