Likewise, in mice with cisplatin-induced AKI, activating SIRT3 with honokiol, a polyphenol derived from the magnolia tree, improved ß-Ox, decreasing ROS levels and fibrosis; meanwhile, these protective effects were lost in SIRT3 knockout mice, emphasizing its participation (Li et al. 2020). This evidence concerns the gene SIRT3 and acute kidney injury.