NLRP3 and chronic kidney disease: In this way, CI and CIII reduction in CKD (Aparicio-Trejo et al. 2020a, b) has been related to the NLRP3-NFkB pathway activation (Gong et al. 2016; Kim et al. 2018; Swanson et al. 2019; Aparicio-Trejo et al. 2020a; Nam et al. 2022).