The higher fatty acid synthesis in CKD may also induce NLRP3 pathway activation by the fatty acid synthase (FASN) induction, an enzyme that is upregulated in pro-inflammatory macrophages type I, leading to upregulation of the expression of the inflammasome components: NLRP3, caspase 1 and pro-IL-1β (Olona et al. 2022). Here, FASN is linked to chronic kidney disease.