The P-aP-DTT-LMP-g4 polyplex NP system targets the Lmp1 oncogene to downregulate the expression of LMP1 protein, which displays antitumor activity both in vitro and in vivo, indicating the potential for gene therapy in EBV-related nasopharyngeal carcinoma [82]. Here, PDLIM7 is linked to nasopharyngeal carcinoma.