In accordance with the principle of base complementarity, the RNP complex was applied to assemble with CuS-DNA to form CuS-RNP@PEI, which can release RNP into the cytoplasm via a double-chain break induced by optothermal radiation provided by NIR-triggered CuS; moreover, tumor ablation and ICD was induced upon NIR-triggered photothermal ablation (∼47 °C) via CuS NPs [86]. Here, RNPC3 is linked to neoplasm.