NUDT21 and idiopathic pulmonary fibrosis: CFIm25 is downregulated in the lungs of IPF patients and bleomycin-treated mice, and the knockdown of CFIm25 caused the upregulation of the fibrotic markers collagen I (COL1A1) and fibronectin in healthy lung fibroblasts and exacerbated fibrosis in bleomycin-treated mice [106].