There is an epigenetic feedback loop between the miR-17~92 cluster and DNA methyltransferase-1 (DNMT-1) expression where DNMT-1 is overexpressed in IPF patients, inducing the epigenetic silencing of miR-17~92, which normally regulates DNMT-1 expression [73]. The gene discussed is DNMT1; the disease is idiopathic pulmonary fibrosis.