IL4 and colorectal carcinoma: Contrastingly, a study by Meng et al. concluded that B7-H3 was capable of enhancing TNF-α production, with B7-H3 silencing leading to reduced levels of TNF-α, IL-2, IL-4, and IFN-γ, while TNF-α itself could upregulate B7-H3 expression in colorectal carcinoma [71].