In various cancers, including malignant glioma, gastric cancer, salivary adenoid cystic carcinoma, and hepatocellular carcinoma (HCC), B7-H3 promotes epithelial-to-mesenchymal transition (EMT) via the activation of the JAK2/STAT3/Slug signaling pathway [43,44,45]. This evidence concerns the gene STAT3 and hepatocellular carcinoma.