CD4 and esophageal squamous cell carcinoma: In the murine models of induced esophageal squamous cell carcinoma (ESCC) with whole-body B7-H3 knockout, enhanced densities of CD8+ TILs were observed, while CD4 T cell density remained comparable to wild-type controls, a finding that was similarly reflected in models with epithelial B7-H3 silencing [59].