PDK1 and colorectal cancer: Similarly, in breast and colorectal cancers, B7-H3 exerts comparable effects by inhibiting Nrf2, thereby regulating critical metabolic enzymes such as hypoxia-inducible factor 1-alpha (HIF1α), lactate dehydrogenase A (LDHA), and pyruvate dehydrogenase kinase 1 (PDK1) [96].