In gastric cancer, mesenchymal stem cells (GCMSCs) have been implicated in inducing chemoresistance to oxaliplatin (OXA) and Paclitaxel (PTX) through the regulation of hexokinase 2 (HK2), possibly involving the TNF-α/p38 signaling pathway, with B7-H3 silencing mitigating this effect [97]. This evidence concerns the gene CD276 and gastric cancer.