Decreased cellular adhesion proteins were also noted during differentiation of type XIV OI, including decreases in some of the cadherin-related pathways that we see here (CELSR2, PCDHGA7, PCDHGA12, ICAM1, and TJP1) [44], suggesting that it may be a common mechanism of multiple OI types. The gene discussed is ICAM1; the disease is osteogenesis imperfecta.