NF-κB activation by ROS contributes to neuroinflammation and neurodegenerative diseases [37].Upregulation of pro-inflammatory cytokines (IL-6) accelerates neuronal damage [38].Chronic NF-κB activation in glial cells exacerbates oxidative stress and neurotoxicity [38]. The gene discussed is NFKB1; the disease is neurodegenerative disease.