HSPA1A and juvenile Huntington disease: Hsp70 also plays a vital role in managing protein aggregates in polyglutamine (polyQ) expansion disorders, such as Huntington’s disease (HD), Kennedy’s spinal and bulbar muscular atrophy, spinocerebellar ataxias, and Machado–Joseph disease [142,143] Elevated levels of Hsp70 and Hsc70 effectively inhibit polyQ protein aggregation and delay disease progression [144].