HSPA5 and Parkinson disease: Similarly, in Parkinson’s disease (PD)—a progressive neurodegenerative disorder characterized by the loss of midbrain dopaminergic neuron (mDA)—interventions such as dietary restriction and 2-deoxyglucose administration have been shown to upregulate Hsp70 and Grp78, providing significant neuroprotection in PD models (Figure 4) [140].