FASN and breast carcinoma: To corroborate this finding, Schroeder et al. demonstrated that FASN inhibition by the FASN inhibitor C75 induces apoptotic cell death in BT-474, MCF-7, MDA-MB-231 breast cancer cells by promoting ROS-dependent mitochondrial cytochrome c release and upregulating pro-apoptotic factors, such as BIM, NOXA, and PUMA [129].