The authors further demonstrated that ACLY inhibition by siRNAs enhances the apoptosis of PC-3 and LNCaP prostate cancer cells induced by Cucurbitacin B [115] and that Cucurbitacin B downregulates the expression of ACLY in PC-3 and LNCaP prostate cancer cells [115]. The gene discussed is ACLY; the disease is Familial prostate cancer.