ESR1 and breast carcinoma: Another study demonstrated that PRDX1 knockdown results in oxidative stress-induced suppression of ERα in T-47D and ZR-75-1 breast cancer cells [210] and sensitizes MCF-7, ZR-75-1, T-47D, MDA-MB-231, HCC-1806, and SK-BR-3 breast cancer cells to the cytotoxic effects of oxidative stress-inducing agents [206,211,212].