METTL3 and infection: Although we observed siMETTL3-mediated increased total STAT1, P-STAT1, and MX1 levels even in the absence of VSV-ΔM51 infection in mock-infected cells (“mock” in Fig. 4A) collected at 72 h post-transfection (48 h transfection plus 24 h infection), we wanted to examine if METTL3 depletion established the intrinsic antiviral state before cells were exposed to the virus (at 48 h post-transfection).