Importantly, VSV-ΔM51 infection induced a strong antiviral response in SUIT-2 cells (“SUIT-2, mock-infection, siSCR” vs “SUIT-2, VSV-ΔM51, siSCR”), marked by upregulation of total STAT1, P-STAT1 (Y701), and MX1 (an important antiviral effector ISG, that was previously shown to inhibit VSV-ΔM51 replication) (48, 55, –, 57), while no detectable response was observed in MIA PaCa-2 cells (“MIA PaCa-2, mock-infection, siSCR” vs “MIA PaCa-2, VSV-ΔM51, siSCR”). This evidence concerns the gene STAT1 and infection.