To examine the relationship between basal METTL3 expression levels and VSV protein accumulation, as well as the effects of METTL3 depletion on VSV protein accumulation, PDAC cells were either treated with scramble siRNA (siSCR) or METTL3 siRNA (siMETTL3) for 48 h before being infected with VSV-ΔM51 at a multiplicity of infection (MOI) of 1 (CFPAC-1, HPAF-II, and Hs766t), 0.1 (HPAC, SUIT-2, and T3M4), 0.01 (AsPC-1, Capan-1, Capan-2, and MIA PaCa-2), or mock-infected (underwent the same treatment as VSV-ΔM51 infection but with no virus) (Fig. 1A). The gene discussed is METTL3; the disease is infection.