To simulate the siRNA transfection prior to infection conditions used throughout this study, we decided to test two alternative conditions: (i) 30%-confluent SUIT-2 cells were treated with IFNs for 48 h (mimics a scenario in which cells are exposed to IFN immediately after siRNA transfection) (left part of Fig. 10A), and (ii) 80%-confluent SUIT-2 cells were treated with IFNs for 24 h (mimics a scenario in which IFNs are produced 24 h post-transfection and cells are exposed to them for 24 h only) (right part of Fig. 10A). The gene discussed is IFNA1; the disease is infection.