Also, the level of total STAT1, P-STAT1, and MX1 in uninfected siMETTL3-treated cells was comparable to that with cells infected with VSV-ΔM51 with or without METTL3 depletion, suggesting that siMETTL3-induced antiviral state is activated at a similar level to the innate immune responses induced by VSV-ΔM51 infection. Here, METTL3 is linked to infection.