METTL3 and infection: To investigate the response in A549 compared to SUIT-2 upon METTL3 downregulation (before infection), the medium was collected 48 h after transfection with either siSCR or siMETTL3 and analyzed for the presence of IFNs using the Human Interferon 9-Plex Discovery Assay Array (HDIFN9, Eve Technologies) (Fig. 14B).