At baseline, age, BMI, adenoma size, 25OHD, ACTH, 1mg-DST, and UFC levels and prevalence of hypertension were not different between the 2 groups, while LS and FN BMD and prevalence of type 2 diabetes was lower in Study 1-A than in Study 1-B group. Here, POMC is linked to type 2 diabetes mellitus.