KLK3 and pure red-cell aplasia: Of the 187 participants diagnosed with PrCa, 100 had either a high PSA level (>3.0 ug/L) or a PI-RADS 3-5 lesion; only 30 (16.0%) had both a high PSA level and a PI-RADS 3-5 lesion, that together comprise the standard criterion in the traditional management pathway for progressing to prostate biopsy (Figure 2, Table 2).