Several chemoattractants, such as CXCL1, CXCL2, CXCL3, CXCL5, CXCL7, and CXCL15, have been reported to recruit MDSCs through binding to CXCR2.[37] Transcriptomic analysis revealed a significant downregulation of CXCL1, CXCL2, CXCL3, and CXCL5 expression in C2–4 KO CRC tissues compared to WT and C1 KO CRC tissues (Figure 6D). This evidence concerns the gene CXCL3 and colorectal carcinoma.