To further investigate the effect of Caspase‐6‐mediated GSDMC activation on tumor development, we intraperitoneally injected vehicle or 5mg kg−1 Caspase‐6 inhibitor Z‐VEID‐FMK every other day for 30 days, starting at day 40 of the AOM‐DSS induced CRC mouse model. The gene discussed is CASP6; the disease is colorectal carcinoma.