Hypoxia and low‐glucose conditions are commonly observed in regions surrounding necrotic tumor cells and could profoundly influence TME to limit immune responses.[6, 23, 24, 25] Interestingly, we noticed that the GSDMC‐expressing CT26 tumors in syngeneic mice frequently displayed areas of necrosis compared to size‐matched control tumors (Figure4A). The gene discussed is DDX53; the disease is neoplasm.