CXCR2 and colorectal carcinoma: To determine whether decreased MDSC infiltration was responsible for the attenuated CRC progression in Gsdmc2–4 deficiency mice, we intraperitoneally injected vehicle or 10 mg kg−1 CXCR2 antagonist SB225002 every 3 days for 30 days, starting at day 40 of the AOM‐DSS induced CRC model.