CXCR2 and colorectal carcinoma: CXCR2 is the receptor for CXCLs, and deletion of CXCR2 has been shown to inhibit the infiltration of MDSCs into the colonic mucosa and tumors.[38] Indeed, MDSCs in CRC tissues highly expressed CXCR2, and immunofluorescence staining revealed co‐localization of CXCR2 with GR‐1 (Figure S9D, Supporting Information).