found that under hypoxia conditions, TNFα plus CHX induced breast cancer cell pyroptosis through Caspase‐8 mediated GSDMC cleavage.[16] In the present study, we found that hypoxia and low‐glucose directly induced colon cancer cell pyroptosis through Caspase‐6 mediated GSDMC activation. The gene discussed is CASP6; the disease is colonic neoplasm.