HMGB1 and neoplasm: Thus, PMN‐MDSCs are recruited primarily by CXC chemokines, including CXCL1, CXCL2, and CXCL5.[43] In the present study, HMGB1 released from pyroptotic tumor cells induced the upregulation of CXCL2 in tumor cells; thus, contributing to the fundamental recruitment of PMN‐MDSCs.