These findings suggest that the enhanced angiogenesis observed in WT CRC tissues is mediated through MDSC‐dependent mechanisms, which aligns with previous reports.[35] These data demonstrate that GSDMC2/3/4 promote colorectal tumor development through CXCL2/CXCR2‐mediated recruitment of MDSCs into the tumor microenvironment. Here, CXCR2 is linked to colorectal neoplasm.