To study the role of GSDMC in tumor pathogenesis, we first assessed the expression of four GSDMC orthologs in mouse tissues and found abundant mRNA expression of GSDMC2, GSDMC3, and GSDMC4 in colon tissue; while, GSDMC1 mRNA expression was relatively low (Figure S2A, Supporting Information). This evidence concerns the gene GSDMC and neoplasm.