Focused analysis of tumor‐associated macrophage (TAM) polarization, dendritic cell (DC) maturation, and cytotoxic T‐cell infiltration showed that the biomimetic codelivery system shifted TAMs toward an M1 phenotype, as evidenced by increased CD86 and MHC‐II expression and decreased CD206 and Arg1 expression. This evidence concerns the gene MRC1 and neoplasm.