PFKFB4 and small cell lung carcinoma: These interactions resulted in a binding energy of −7.8 kcal mol−1 for the protein‐ligand complex (Figure 1K,L).To verify whether PFKFB4 affects paclitaxel sensitivity in SCLC, we knocked down PFKFB4 in NCI‐H446 and DMS114 SCLC cell lines (Figure S2A—C, Supporting Information).