FRMD8highERαhigh and FRMD8highPRhigh cells were mainly present in normal tissues adjacent to tumor of MMTV-Cre-; Frmd8fl/fl; PyMT mice, whereas Frmd8 depletion led to FRMD8lowERαlow and FRMD8lowPRlow cells markedly increased (Figure 3—figure supplement 1C and D). This evidence concerns the gene FRMD8 and neoplasm.