FRMD8 and breast carcinoma: The results showed that 5-Aza-dC treatment significantly upregulated both mRNA and protein levels of FRMD8 in claudin-low but not luminal breast cancer cell lines (Figure 6D and E, Figure 6—figure supplement 1A), which was consistent with the lower expression of FRMD8 in claudin-low breast cancer cell lines (Figure 6A).