The analysis indicated that core genes of the GSH metabolism pathway were significantly dysregulated in liver fibrosis patients, particularly those involved in the TCA cycle and closely related to copper death, such as DLD, Succinate Dehydrogenase Complex Subunit B (SDHB), Dihydrolipoamide Acetyltransferase (DLAT) and Dihydrolipoamide Succinyltransferase (DLST), all of which showed significant disruption. The gene discussed is DLST; the disease is Hepatic fibrosis.