Thus, the high detection of Plex (pleckstrin), Trpc6 (transient receptor potential channel 6), Rasa3 (Ras p21 protein activator 3), and Alox12 (arachidonate 12-lipoxygenase) may portend risk of arterial aneurysm rupture while overexpression of SOD2 consistently downregulated these pathways, potentially protecting the animals from aneurysm rupture and sudden death. This evidence concerns the gene RASA3 and aneurysm.