In summary, proteomic profiling and analysis of aortic tissue following augmentation of SOD2 expression revealed enrichment in pathways related to inflammation/inflammatory responses (i.e., STAT3/MAPK signaling), platelet activity, and translation/transcription in addition to oxidative phosphorylation and neutrophil degranulation, pathways that are predominant in human aneurysms 62. Here, STAT3 is linked to aneurysm.