PLEK and aneurysm: Thus, the high detection of Plex (pleckstrin), Trpc6 (transient receptor potential channel 6), Rasa3 (Ras p21 protein activator 3), and Alox12 (arachidonate 12-lipoxygenase) may portend risk of arterial aneurysm rupture while overexpression of SOD2 consistently downregulated these pathways, potentially protecting the animals from aneurysm rupture and sudden death.